The Translational Research Unit (TRU) at the Institute of Pathology of the University of Bern & Lunaphore Technologies SA are seeking a Post-doctoral fellow.
Colorectal cancer is a heterogeneous disease with a tumor microenvironment rich in different cell types, densities and frequencies. Tumor budding at the advancing edge of the cancer has been described as an important prognostic and potentially predictive factor, with features of Epithelial Mesenchymal Transition (EMT), but the characterization of the environment in which it persists has yet to be elucidated. In this project, we investigate the tumor microenvironment of colorectal cancers, using novel microfluidic fluorescence multiplexing technology. In a partnership with Lunaphore Technologies SA (www.lunaphore.ch), we will establish panels of protein markers to characterize this environment and establish analysis pipelines for performing cell phenotyping, spatial analysis and other cellular neighborhood explorations. We aim to combine morphology and protein analysis to achieve a more in-depth phenotypic characterization and translate these into novel insights of colorectal cancer biology and potentially new prognostic biomarkers.
Who are we? We are looking for a Research Scientist to work in strict collaboration with the Application Development Team at Lunaphore Technologies SA. The candidate will be the main scientist involved in a 2-years project granted by the Innosuisse Impulse Program, aimed to resolve the Tumor Budding characterization in colorectal cancer settings. The project requires the use of existing Lunaphore technology on histological samples with the in-house developed microfluidic tools, with applications already defined or still under development. The candidate will join a hard-working team, passionate about taking tissue multiplexing and image analysis to the next level. The position will be mostly based in Tolochenaz (VD) at Lunaphore premises, with occasional travels to the academic partner site in Bern (5-10%).
Responsibility and Duties
Our offerPlace of work: Lunaphore Technologies SA, Tolochenaz (VD), with occasional travels to the academic partner site in Bern (5-10%)
Duration of appointment: 2 years
Start: September 2021
Salary: Competitive and according to the Swiss National Science Foundation
What we can additionally offer
ApplicationPlease send your application beforeJuly 1st, 2021including a short letter of interest, curriculum vitae with description of your professional experience, a list of publications, a list of 2 references, and copies of the certificates of academic qualifications as a single pdf-file by Email to: email@example.com