Postdoctoral Position in development of Coherent Electron Diffractive Imaging at the Laboratory of Biological Electron Microscopy (LBEM)

  • EPFL
  • Lausanne, VD, Switzerland
  • 24/05/2021
Full time Data Science Data Engineering Data Analytics Big Data Data Management Statistics Biostatistician

Job Description

EPFL, the Swiss Federal Institute of Technology in Lausanne, is one of the most dynamic university campuses in Europe and ranks among the top 20 universities worldwide. The EPFL employs more than 6,000 people supporting the three main missions of the institutions: education, research and innovation. The EPFL campus offers an exceptional working environment at the heart of a community of more than 16,000 people, including over 12,000 students and 4,000 researchers from more than 120 different countries.

Postdoctoral Position in development of Coherent Electron Diffractive Imaging at the Laboratory of Biological Electron Microscopy (LBEM)

Your mission :
We have a postdoc opening in our group LBEM at the EPFL in Lausanne, Switzerland, in the area of method development for coherent electron diffractive imaging.

The project aims to develop a system that can determine the structure of frozen hydrated proteins with a cryo-transmission electron microscope, using a high-speed hybrid pixel detector camera and diffractive imaging approaches. Proteins will be frozen in thin, free-standing ice layers as single particles, similarly as used for single particle cryo-EM. However, data will be collected with a probe Cs corrected 300kV Titan Krios cryo-EM instrument in diffraction mode, using a prototype high-speed hybrid pixel detector camera. The project involves development of data collection schemes on the electron microscope, collecting diffractive data at very high frame rates, developing and applying online pre-processing to the data, and developing structure reconstruction methods.

Your profile :
Candidates should have a Ph.D. in Physics, Electrical Engineering, Computer Sciences, or related disciplines, and should have expertise in electron microscopy.

We offer :
The EPFL ranks among the world’s top scientific universities. It is located in Lausanne in Switzerland, a beautiful, vibrant and highly international city on the shores of scenic Lake Geneva, situated within an Alpine setting in the heart of Europe. French is the main language spoken in the city of Lausanne, while English is the main language at the EPFL and in our laboratory. The position comes with a competitive salary. EPFL is committed to being an equal opportunity employer.

The successful postdoc will join a vibrant, collaborative, international, and diverse research team with interdisciplinary expertise in biology, physics, computer science and engineering.
Our lab in the Institute of Physics at the EPFL operates outstanding equipment, including a 300kV Titan Krios with Cold-FEG and Cs probe corrector, and a Talos F200C. We develop methods in cryo-EM and apply these to study neurodegeneration. In addition, the Dubochet Center for Imaging in Lausanne provides access to frontier cryo-EM, including another two Titan Krios instruments.

Start date :
The position is available immediately, the start date is flexible.

Applications should include PDF documents with:

  • cover letter
  • CV
  • contact information of three references.

Term of employment :
Fixed-term (CDD)

Work rate :

Duration :
Fixed-term (CDD)

Contact :
For questions or additional information, please visit or contact Henning Stahlberg at

Remark :
Only candidates who applied through EPFL website or our partner Jobup’s website will be considered. Files sent by agencies without a mandate will not be taken into account